David Deutsch

“Some people become depressed at the scale of the universe, because it makes them feel insignificant. Other people are relieved to feel insignificant, which is even worse. But, in any case, those are mistakes. Feeling insignificant because the universe is large has exactly the same logic as feeling inadequate for not being a cow. Or a herd of cows. The universe is not there to overwhelm us; it is our home, and our resource. The bigger the better.”
“Like every other destruction of optimism, whether in a whole civilisation or in a single individual, these must have been unspeakable catastrophes for those who had dared to expect progress. But we should feel more than sympathy for those people. We should take it personally. For if any of those earlier experiments in optimism had succeeded, our species would be exploring the stars by now, and you and I would be immortal.”

“An unproblematic state is a state without creative thought. Its other name is death.”